Ann McKee
Ann McKee

I'm concerned about the future of football, because we have paid a lot of attention to concussions. We are more aware of concussions. But it's really the repetitive minor injuries, the ones that are asymptomatic that occur on almost every play of the game, the sub-concussive hits: that's the big problem for football.

Anthea Butler
Anthea Butler

Despite a rich history of black Americans involved in the Catholic Church, invisibility is a big problem for black Catholics in America.

Anthony Jeselnik
Anthony Jeselnik

Everyone has the same kind of fears; everyone has the same big problems in the world, which is, like, fear of death and 'I hope horrible things don't happen to my family,' but they do. And I think people laugh at them as this great release.

Astro Teller
Astro Teller

Moonshot thinking starts with picking a big problem: something huge, long existing, or on a global scale.

Astro Teller
Astro Teller

Find some fun way to get a little more oil on your hands or mud on your boots. Sometimes, that's what it takes to take down some of the really big problems.

Barry Silbert
Barry Silbert

Our mission is to accelerate the development of a better financial system; it's not just development of a better Bitcoin financial system, and so we want to back the best teams, who have the biggest ideas, unique solutions to big problems.

Ben Gibbard
Ben Gibbard

At some point, I thought that, as I got older, I'd come to terms with a lot of things. I'd solve some big problems, and eventually I'd become content. It's almost more depressing to think that the older you get, the more your problems multiply.

Ben Quayle
Ben Quayle

And that's the one thing that people do not understand is that we have very low interest rates and if those go back to historical levels or even go back to scary thoughts that they're back in the late '70s, early '80s, then that's going to really be hard to actually pay off those debts. It's going to be a - it's going to be a very big problem.

Bernard Goldberg
Bernard Goldberg

I have a big problem when the sanctimonious, holier than thou congressmen and women go on national television for six hours and beat somebody up with a stick, and not because I'm 'Ms. Manners.' That's not what bothers me. People in glass houses shouldn't throw stones.

Beth Ostrosky Stern
Beth Ostrosky Stern

Dog obesity is a big problem in this country.